Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus

被引：23

作者：

Kang, Hahk-Soo ^{[1
]}

Kim, Kyoung-Rok ^{[2
]}

Jun, Eun-Mi ^{[1
]}

Park, Soon-Hye ^{[1
]}

Lee, Tae-Soo ^{[3
]}

Suh, Joo-Won ^{[2
]}

Kim, Jong-Pyung ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Funct Metabolite Res Ctr, Taejon 305806, South Korea

[2] Myongji Univ, Div Biosci & Bioinformat, Dept Biol Sci, Yongin 449728, South Korea

[3] Univ Incheon, Dept Biol, Inchon 402709, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期

关键词：

Cyathus stercoreus; DNA protection; free radical scavenger; polyketide;

D O I：

10.1016/j.bmcl.2008.05.110

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS(+), DPPH, and superoxide anion radicals. Cyathuscavins A-C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A-C protected supercoiled plasmid DNA from Fe(2+)/H(2)O(2)- induced breakage. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4047 / 4050

页数：4

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