Peptidomimetics, a synthetic tool of drug discovery

被引：429

作者：

Vagner, Josef ^{[3
]}

Qu, Hongchang ^{[1
,2
]}

Hruby, Victor J. ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Biochem & Mol Biophys, Tucson, AZ 85721 USA

[3] Univ Arizona, Bio Inst 5, Tucson, AZ 85721 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2008年 / 12卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2008.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

引用

页码：292 / 296

页数：5

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