Safe use of sorafenib in a patient undergoing salvage liver transplantation for recurrent hepatocellular carcinoma after hepatic resection

被引:7
作者
Kim, Richard [2 ]
Menon, Narayanan
Aucejo, Federico [1 ]
机构
[1] Cleveland Clin, Liver Tumor Clin, Cleveland, OH 44195 USA
[2] Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44195 USA
关键词
Hepatocellular carcinoma; Liver transplantation; Neoadjuvant therapy; Anti-angiogenic therapy; Sorafenib; TRANSARTERIAL CHEMOEMBOLIZATION;
D O I
10.1007/s12032-010-9625-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Sorafenib, a multikinase inhibitor targeting angiogenesis, cell survival, and proliferation in hepatocellular carcinoma (HCC) is a standard therapy for advanced stage disease. However, its utilization as neoadjuvant therapy is under investigation and remains an off label indication. The use of sorafenib in pre-liver transplant setting raises caveats associated with risk of bleeding, wound healing deficiencies, and hepatic decompensation. Herein, we report the case of a patient who after exhibiting HCC relapse post-hepatic resection underwent sorafenib therapy and subsequent transplantation. Sorafenib was well tolerated, and no adverse events were noticed. The use of sorafenib as neoadjuvant therapy in pre-transplant patients is feasible and deserves investigation in large clinical settings.
引用
收藏
页码:1044 / 1047
页数:4
相关论文
共 10 条
  • [1] Outcomes of Neoadjuvant Transarterial Chemoembolization to Downstage Hepatocellular Carcinoma Before Liver Transplantation
    Chapman, William C.
    Doyle, M. B. Majella
    Stuart, Jourdan E.
    Vachharajani, Neeta
    Crippin, Jeffrey S.
    Anderson, Christopher D.
    Lowell, Jeffrey A.
    Shenoy, Surendra
    Darcy, Michael D.
    Brown, Daniel B.
    [J]. ANNALS OF SURGERY, 2008, 248 (04) : 617 - 624
  • [2] Tumor response to transcatheter arterial chemoembolization in recurrent hepatocellular carcinoma after living donor liver transplantation
    Ko, Heung-Kyu
    Ko, Gi-Young
    Yoon, Hyun Ki
    Sung, Kyu-Bo
    [J]. KOREAN JOURNAL OF RADIOLOGY, 2007, 8 (04) : 320 - 327
  • [3] Hepatocellular carcinoma
    Llovet, JM
    Burroughs, A
    Bruix, J
    [J]. LANCET, 2003, 362 (9399) : 1907 - 1917
  • [4] Sorafenib in advanced hepatocellular carcinoma
    Llovet, Josep M.
    Ricci, Sergio
    Mazzaferro, Vincenzo
    Hilgard, Philip
    Gane, Edward
    Blanc, Jean-Frederic
    Cosme de Oliveira, Andre
    Santoro, Armando
    Raoul, Jean-Luc
    Forner, Alejandro
    Schwartz, Myron
    Porta, Camillo
    Zeuzem, Stefan
    Bolondi, Luigi
    Greten, Tim F.
    Galle, Peter R.
    Seitz, Jean-Francois
    Borbath, Ivan
    Haussinger, Dieter
    Giannaris, Tom
    Shan, Minghua
    Moscovici, Marius
    Voliotis, Dimitris
    Bruix, Jordi
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) : 378 - 390
  • [5] Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
    Mazzaferro, V
    Regalia, E
    Doci, R
    Andreola, S
    Pulvirenti, A
    Bozzetti, F
    Montalto, F
    Ammatuna, M
    Morabito, A
    Gennari, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (11) : 693 - 699
  • [6] Response to transarterial chemoembolization as a biological selection criterion for liver transplantation in hepatocellular carcinoma
    Otto, Gerd
    Herber, Sascha
    Heise, Michael
    Lohse, Ansgar W.
    Moench, Christian
    Bittinger, Fernando
    Hoppe-Lotichius, Maria
    Schuchmann, Marcus
    Victor, Anja
    Pitton, Michael
    [J]. LIVER TRANSPLANTATION, 2006, 12 (08) : 1260 - 1267
  • [7] Printz Carrie, 2009, Cancer, V115, P4646, DOI 10.1002/cncr.24673
  • [8] Current Management of Hepatocellular Cancer
    Rampone, Bernardino
    Schiavone, Beniamino
    Confuorto, Giuseppe
    [J]. CURRENT ONCOLOGY REPORTS, 2010, 12 (03) : 186 - 192
  • [9] Prognostic factors and recurrence of small hepatocellular carcinoma after hepatic resection or microwave ablation: A retrospective study
    Wang, Zhi Li
    Liang, Ping
    Dong, Bao Wei
    Yu, Xiao Ling
    Yu, De Jiang
    [J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2008, 12 (02) : 327 - 337
  • [10] Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: An intention-to-treat analysis
    Yao, Francis Y.
    Kerlan, Robert K., Jr.
    Hirose, Ryutaro
    Davern, Timothy J., III
    Bass, Nathan M.
    Feng, Sandy
    Peters, Marion
    Terrault, Norah
    Freise, Chris E.
    Ascher, Nancy L.
    Roberts, John P.
    [J]. HEPATOLOGY, 2008, 48 (03) : 819 - 827