Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

被引：9

作者：

Bang, EunJin ^{[1
]}

Lee, Bonggi ^{[2
]}

Noh, Sang-Gyun ^{[1
]}

Kim, Dae Hyun ^{[1
]}

Jung, Hee Jin ^{[1
]}

Ha, Sugyeong ^{[1
]}

Yu, Byung Pal ^{[3
]}

Chung, Hae Young ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Dept Pharm, Busan 46241, South Korea

[2] KIOM, Korean Med KM Applicat Ctr, Daegu 41062, South Korea

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

来源：

BMB REPORTS | 2019年 / 52卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Aging; Chronic inflammation; CR; Omics big data; Senoinflammation; NF-KAPPA-B; INFLAMMATORY NETWORKS; INSULIN SENSITIVITY; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; AGE; EXPRESSION; ACTIVATION; INDUCTION; MECHANISM;

D O I：

10.5483/BMBRep.2019.52.1.301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.

引用

页码：56 / 63

页数：8

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