Methylation patterns of cutaneous T-cell lymphomas

被引：7

作者：

Izykowska, Katarzyna ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60461 Poznan, Poland

来源：

EXPERIMENTAL DERMATOLOGY | 2021年 / 30卷 / 08期

关键词：

cutaneous T-cell lymphoma; DNA methyltransferases; epigenetics; methylation; TET; TUMOR-SUPPRESSOR GENES; DNA METHYLATION; SEZARY-SYNDROME; EXPRESSION; P16; APOPTOSIS; PATHWAY; PROTEIN; GENOME; RISK;

D O I：

10.1111/exd.14108

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In cutaneous T-cell lymphoma (CTCL), global hypomethylation of the genome and hypermethylation of tumor suppressor genes were detected. Studies show that methylation dysregulation is often a starting point for processes that might lead to malignant transformation. In this review, all data regarding copy-number variations (CNVs) and mutations in main methylation players DNA methyltransferases/TET in CTCL were summarized. An overview of studies on gene-specific hypomethylation and hypermethylation in CTCL, including methylation of microRNA genes, was presented. The possibility of using the methylation pattern in diagnosis and methylation inhibitors in treatment of CTCL was discussed.

引用

页码：1135 / 1140

页数：6

共 29 条

[1] Genomic landscape of cutaneous T cell lymphoma [J].

Choi, Jaehyuk ;

Goh, Gerald ;

Walradt, Trent ;

Hong, Bok S. ;

Bunick, Christopher G. ;

Chen, Kan ;

Bjornson, Robert D. ;

Maman, Yaakov ;

Wang, Tiffany ;

Tordoff, Jesse ;

Carlson, Kacie ;

Overton, John D. ;

Liu, Kristina J. ;

Lewis, Julia M. ;

Devine, Lesley ;

Barbarotta, Lisa ;

Foss, Francine M. ;

Subtil, Antonio ;

Vonderheid, Eric C. ;

Edelson, Richard L. ;

Schatz, David G. ;

Boggon, Titus J. ;

Girardi, Michael ;

Lifton, Richard P. .

NATURE GENETICS, 2015, 47 (09) :1011-+

[2] The mutational landscape of cutaneous T cell lymphoma and Sezary syndrome [J].

da Silva Almeida, Ana Carolina ;

Abate, Francesco ;

Khiabanian, Hossein ;

Martinez-Escala, Estela ;

Guitart, Joan ;

Tensen, Cornelis P. ;

Vermeer, Maarten H. ;

Rabadan, Raul ;

Ferrando, Adolfo ;

Palomero, Teresa .

NATURE GENETICS, 2015, 47 (12) :1465-+

[3] A specific DNA methylation profile correlates with a high risk of disease progression in stage I classical (Alibert-Bazin type) mycosis fungoides [J].

Ferrara, G. ;

Pancione, M. ;

Votino, C. ;

Quaglino, P. ;

Tomasini, C. ;

Santucci, M. ;

Pimpinelli, N. ;

Cusano, F. ;

Sabatino, L. ;

Colantuoni, V. .

BRITISH JOURNAL OF DERMATOLOGY, 2014, 170 (06) :1266-1275

[4] Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies [J].

Fratta, Elisabetta ;

Montico, Barbara ;

Rizzo, Aurora ;

Colizzi, Francesca ;

Sigalotti, Luca ;

Dolcetti, Riccardo .

ONCOTARGET, 2016, 7 (35) :57327-57350

[5]

Gallardo F, 2004, HAEMATOLOGICA, V89, P1401

[6] Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides [J].

Gallardo, Fernando ;

Sandoval, Juan ;

Diaz-Lagares, Angel ;

Garcia, Ricard ;

D'Altri, Teresa ;

Gonzalez, Jessica ;

Alegre, Victor ;

Servitje, Octavio ;

Crujeiras, Ana-Belen ;

Stefansson, Olafur-Andri ;

Espinet, Blanca ;

Hernandez, Maria-Inmaculada ;

Bellosillo, Beatriz ;

Esteller, Manel ;

Pujol, Ramon-Maria ;

Bigas, Anna ;

Espinosa, Lluis .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (12) :3144-3152

[7] Inactivation of RUNX3/p46 Promotes Cutaneous T-Cell Lymphoma [J].

Haider, Ahmed ;

Steininger, Anne ;

Ullmann, Reinhard ;

Hummel, Michael ;

Dimitrova, Lora ;

Beyer, Marc ;

Vandersee, Staffan ;

Lenze, Dido ;

Sterry, Wolfram ;

Assaf, Chalid ;

Moebs, Markus .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2016, 136 (11) :2287-2296

[8] Connections between TET proteins and aberrant DNA modification in cancer [J].

Huang, Yun ;

Rao, Anjana .

TRENDS IN GENETICS, 2014, 30 (10) :464-474

[9] Genetic rearrangements result in altered gene expression and novel fusion transcripts in Sezary syndrome [J].

Izykowska, Katarzyna ;

Przybylski, Grzegorz K. ;

Gand, Claudia ;

Braun, Floriane C. ;

Grabarczyk, Piotr ;

Kuss, Andreas W. ;

Olek-Hrab, Karolina ;

Torres, Armando N. Bastidas ;

Vermeer, Maarten H. ;

Zoutman, Willem H. ;

Tensen, Cornelis P. ;

Schmidt, Christian A. .

ONCOTARGET, 2017, 8 (24) :39627-39639

[10]

Jawed S. I., 2014, J AM ACAD DERMATOL, V70, P205

← 1 2 3 →