Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus

被引：7
|
作者：
Ilic, Slavica B. [1 ]
Konstantinovic, Sandra S. [1 ]
Veljkovic, Vlada B. [1 ]
Savic, Dragisa S. [1 ]
Lazic, Miodrag L. [1 ]
Gojgic-Cvijovic, Gordana [2 ]
机构：
[1] Fac Technol, Leskovac, Serbia
[2] Inst Chem Technol & Met, Belgrade 11000, Serbia
来源：
CURRENT MICROBIOLOGY | 2008年 / 57卷 / 01期
关键词：
Fermentation; Extracellular Polymeric Substance; Fermentation Broth; Antibiotic Production; Submerged Fermentation;
D O I：
10.1007/s00284-008-9143-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm(3)) and azalomycine (188.6 mg/dm(3)) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
引用
收藏
页码：8 / 11
页数：4
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