Gold nanorods for applications in biological imaging

被引：6
作者：
Zhang, Y. [1 ]
Yu, J. [2 ]
Birch, D. J. S. [1 ]
Chen, Y. [1 ]
机构：
[1] Univ Strathclyde, Dept Phys, Photophys Grp, Ctr Mol Nanometrol,SUPA, John Anderson Bldg,107 Rottenrow, Glasgow G4 0NG, Lanark, Scotland
[2] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G1 1XW, Lanark, Scotland
来源：
REPORTERS, MARKERS, DYES, NANOPARTICLES, AND MOLECULAR PROBES FOR BIOMEDICAL APPLICATIONS III | 2011年 / 7910卷
基金：
英国工程与自然科学研究理事会;
关键词：
gold nanorods; surface plasmon; two-photon luminescence; fluorescence lifetime imaging; METAL-ENHANCED FLUORESCENCE; OPTICAL-PROPERTIES; CONTRAST AGENTS; NANOPARTICLES; CELLS; LUMINESCENCE; MICROSCOPY; EMISSION; TIME; PHOTOLUMINESCENCE;
D O I：
10.1117/12.877156
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Two-Photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging for high resolution, low photo-damage, tunable near infra-red (NIR) longitudinal band, polarization dependence, ability to conjugate to bio-molecules and low toxicity. Here we demonstrate the application of gold nanorods as TPL imaging agents by studying the gold nanorods taken up by Madin-Darby canine kidney (MDCK) cells using both confocal imaging and fluorescence lifetime imaging microscopy (FLIM). The characteristic luminescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.
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页数：6
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