How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

被引:6
作者
Mylonakis, Sophia C. [1 ]
Mylona, Evangelia K. [1 ]
Kalligeros, Markos [1 ,2 ]
Shehadeh, Fadi [1 ,3 ]
Chan, Philip A. [1 ,4 ]
Mylonakis, Eleftherios [1 ]
机构
[1] Brown Univ, Warren Alpert Med Sch, Infect Dis Div, Providence, RI 02903 USA
[2] Brown Univ, Warren Alpert Med Sch, Dept Med, Providence, RI 02903 USA
[3] Natl Tech Univ Athens, Sch Elect & Comp Engn, Athens 15780, Greece
[4] Rhode Isl Dept Hlth, Div Preparedness Response Infect Dis & Emergency, Providence, RI 02908 USA
关键词
influenza; children; diabetes; length of stay; metabolic diseases; UNITED-STATES; CHILDREN; COMPLICATIONS; INFECTION; COVID-19; RATES; RISK;
D O I
10.3390/ijerph19052811
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severity of influenza in children. We used a statewide network in Rhode Island, USA, to extract data for laboratory-confirmed influenza cases among children 19 years old or younger. We identified 1169 lab-confirmed influenza cases. The most common comorbidities were asthma (17.1%), neurodevelopmental disorders (10.3%), gastrointestinal disorders (7.6%), atopic dermatitis (7%), and endocrine and metabolic diseases (6.8%). Interestingly, 80.8% (63 out of 78) of children who had an influenza-related hospital admission had at least one comorbidity, and among hospitalized children with influenza, the most common comorbidities were neurological diseases (28.2%, 22/78), gastrointestinal disorders (25.6%, 20/78), endocrine and metabolic diseases (24.4%, 19/78), and neurodevelopmental disorders (23.1%, 18/78). Children with endocrine or metabolic diseases were 8.23 times more likely to be admitted to the hospital, and children with neurological disorders were 6.35 times more likely to be admitted (OR: 8.23, 95% CI: 4.42-15.32 and OR: 6.35, 95% CI: 3.60-11.24, respectively). In summary, we identified specific comorbidities associated with influenza hospitalization and length of hospital stay, and these groups should be prioritized for public health interventions.
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页数:9
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共 27 条
  • [1] Assessment of pulmonary function by impulse oscillometry and spirometry in children with type 1 diabetes mellitus
    Anik, Ayse
    Anik, Ahmet
    Uysal, Pinar
    [J]. PEDIATRIC PULMONOLOGY, 2020, 55 (12) : 3517 - 3524
  • [2] Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry
    Bhalala, Utpal S.
    Gist, Katja M.
    Tripathi, Sandeep
    Boman, Karen
    Kumar, Vishakha K.
    Retford, Lynn
    Chiotos, Kathleen
    Blatz, Allison M.
    Dapul, Heda
    Verma, Sourabh
    Sayed, Imran A.
    Gharpure, Varsha P.
    Bjornstad, Erica
    Tofil, Nancy
    Irby, Katherine
    Sanders, Ronald C., Jr.
    Heneghan, Julia A.
    Thomas, Melissa
    Gupta, Manoj K.
    Oulds, Franscene E.
    Arteaga, Grace M.
    Levy, Emily R.
    Gupta, Neha
    Kaufman, Margit
    Abdelaty, Amr
    Shlomovich, Mark
    Medar, Shivanand S.
    O'Meara, A. M. Iqbal
    Kuehne, Joshua
    Menon, Shina
    Khandhar, Paras B.
    Miller, Aaron S.
    Barry, Suzanne M.
    Danesh, Valerie C.
    Khanna, Ashish K.
    Zammit, Kimberly
    Stulce, Casey
    McGonagill, Patrick W.
    Bercow, Asher
    Amzuta, Ioana G.
    Gupta, Sandeep
    Almazyad, Mohammed A.
    Pierre, Louisdon
    Sendi, Prithvi
    Ishaque, Sidra
    Anderson, Harry L., III
    Nawathe, Pooja
    Akhter, Murtaza
    Lyons, Patrick G.
    Chen, Catherine
    [J]. CRITICAL CARE MEDICINE, 2022, 50 (01) : E40 - E51
  • [3] Risk for In-Hospital Complications Associated with COVID-19 and Influenza - Veterans Health Administration, United States, October 1, 2018-May 31, 2020
    Cates, Jordan
    Lucero-Obusan, Cynthia
    Dahl, Rebecca M.
    Schirmer, Patricia
    Garg, Shikha
    Oda, Gina
    Hall, Aron J.
    Langley, Gayle
    Havers, Fiona P.
    Holodniy, Mark
    Cardemil, Cristina, V
    [J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (42): : 1528 - 1534
  • [4] Centers for Disease Control and Prevention National Center for Immunization and Respiratory Diseases (NCIRD), DIS BURD INFL
  • [5] Differences in severity-adjusted pediatric hospitalization rates are associated with race/ethnicity
    Chamberlain, James M.
    Joseph, Jill G.
    Patel, Kantilal M.
    Pollack, Murray M.
    [J]. PEDIATRICS, 2007, 119 (06) : E1319 - E1324
  • [6] Risk Factors for Influenza Virus Related Severe Lower Respiratory Tract Infection in Children
    Eski, Aykut
    Ozturk, Gokcen Kartal
    Gulen, Figen
    Cicek, Candan
    Demir, Esen
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2019, 38 (11) : 1090 - 1095
  • [7] Outcomes of SARS-CoV-2-Positive Youths Tested in Emergency Departments The Global PERN-COVID-19 Study
    Funk, Anna L.
    Florin, Todd A.
    Kuppermann, Nathan
    Tancredi, Daniel J.
    Xie, Jianling
    Kim, Kelly
    Neuman, Mark, I
    Ambroggio, Lilliam
    Plint, Amy C.
    Mintegi, Santiago
    Klassen, Terry P.
    Salvadori, Marina, I
    Malley, Richard
    Payne, Daniel C.
    Simon, Norma-Jean
    Yock-Corrales, Adriana
    Nebhrajani, Jasmine R.
    Chaudhari, Pradip P.
    Breslin, Kristen A.
    Finkelstein, Yaron
    Campos, Carmen
    Bergmann, Kelly R.
    Bhatt, Maala
    Ahmad, Fahd A.
    Gardiner, Michael A.
    Avva, Usha R.
    Shah, Nipam P.
    Sartori, Laura F.
    Sabhaney, Vikram J.
    Caperell, Kerry
    Navanandan, Nidhya
    Borland, Meredith L.
    Morris, Claudia R.
    Gangoiti, Iker
    Pavlicich, Viviana
    Kannikeswaran, Nirupama
    Lunoe, Maren M.
    Rino, Pedro B.
    Kam, April J.
    Cherry, Jonathan C.
    Rogers, Alexander J.
    Chong, Shu-Ling
    Palumbo, Laura
    Angelats, Carlos M.
    Morrison, Andrea K.
    Kwok, Maria Y.
    Becker, Sarah M.
    Dixon, Andrew C.
    Poonai, Naveen
    Eckerle, Michelle
    [J]. JAMA NETWORK OPEN, 2022, 5 (01) : E2142322
  • [8] Impact of congenital heart disease on outcomes among pediatric patients hospitalized for influenza infection
    Ghimire, Laxmi V.
    Chou, Fu-Sheng
    Moon-Grady, Anita J.
    [J]. BMC PEDIATRICS, 2020, 20 (01)
  • [9] Neurological Manifestations of Influenza Infection in Children and Adults: Results of a National British Surveillance Study
    Goenka, Anu
    Michael, Benedict D.
    Ledger, Elizabeth
    Hart, Ian J.
    Absoud, Michael
    Chow, Gabriel
    Lilleker, James
    Lunn, Michael
    McKee, David
    Peake, Deirdre
    Pysden, Karen
    Roberts, Mark
    Carrol, Enitan D.
    Lim, Ming
    Avula, Shivaram
    Solomon, Tom
    Kneen, Rachel
    [J]. CLINICAL INFECTIOUS DISEASES, 2014, 58 (06) : 775 - 784
  • [10] Diabetes is a major cause of influenza-associated mortality in Mexico
    Gomez-Gomez, A.
    Sanchez-Ramos, E. L.
    Noyola, D. E.
    [J]. REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE, 2021, 69 (04): : 205 - 213