Adipose-Secreted Exosomes and Their Pathophysiologic Effects on Skeletal Muscle

被引:6
作者
Yue, Binglin [1 ]
Wang, Hui [1 ]
Cai, Xin [1 ]
Wang, Jiabo [1 ]
Chai, Zhixin [1 ]
Peng, Wei [2 ]
Shu, Shi [2 ]
Fu, Changqi [2 ]
Zhong, Jincheng [1 ]
机构
[1] Southwest Minzu Univ, Key Lab Qinghai Tibetan Plateau Anim Genet Resour, Sichuan Prov & Minist Educ, Chengdu 610225, Peoples R China
[2] Qinghai Univ, Acad Anim Sci & Vet Med, Xining 810016, Peoples R China
关键词
exosome; adipose tissue; skeletal muscle; EXTRACELLULAR VESICLES; CELL COMMUNICATION; INSULIN-RESISTANCE; GENE-EXPRESSION; TISSUE; ADIPOCYTES; BIOGENESIS; FAT; CROSSTALK; BIOLOGY;
D O I
10.3390/ijms232012411
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Due to its prominent secretory activity, adipose tissue (AT) is now considered a major player in the crosstalk between organs, especially with skeletal muscle. In which, exosomes are effective carriers for the intercellular material transfer of a wide range of molecules that can influence a series of physiological and pathological processes in recipient cells. Considering their underlying roles, the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle have received great attention in the field. In this review, we describe what is currently known of adipose-secreted exosomes, as well as their applications in skeletal muscle pathophysiology.
引用
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页数:13
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