Three-dimensional determination of absorbed dose by spectrophotometric analysis of ferrous-sulphate agarose gel

We describe a technique to obtain three-dimensional (3-D) imaging of an absorbed dose by optical transmittance measurements of phantoms composed by agarose gel in which a ferrous sulphate and xylenol orange solution are incorporated, The analysis of gel samples is performed by acquiring transmittance images with a system based on a CCD camera provided with an interference filter matching the optical absorption peak of interest. The proposed technique for 3-D measurements of an absorbed dose is based on the imaging of phantoms composed of sets of properly piled up gel slices. The slice thickness was optimized in order to obtain a good image contrast as well as a good in-depth spatial resolution. To test the technique, a phantom has been irradiated with a collimated gamma-beam and then analysed. Proper software was adapted in order to visualise the images of all slices and to attain the 2-D profiles of the dose absorbed by each slice. (C) 1999 Elsevier Science B.V. All rights reserved.