Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif

被引：26

作者：

Ayoup, Mohammed Salah ^{[1
,2
]}

Cordes, David B. ^{[1
]}

Slawin, Alexandra M. Z. ^{[1
]}

O'Hagan, David ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Univ Alexandria, Fac Sci, Dept Chem, Alexandria, Egypt

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

EFFICIENT; ESTERS;

D O I：

10.1039/c5ob00650c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated into illustrative dipeptides via the free amine and carboxylate respectively demonstrating its utility as a novel amino acid for peptide synthesis and offering a vehicle for incorporation of this unique and facially polarized ring system into bioactive compounds.

引用

页码：5621 / 5624

页数：4

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