Cognitive enhancement in aged rats after chronic administration of Equisetum arvense L. with demonstrated antioxidant properties in vitro

被引:19
作者
dos Santos, JG
Hoffmann, F
do Martins, D
Blanco, MM
Lanziotti, VMDB
Maia, FD
Leal, LKD
机构
[1] Univ Fed Sao Paulo, Dept Physiol, Lab Neurofisiol, Sao Paulo, Brazil
[2] Univ Fed Santa Catarina, Dept Morphophysiol, BR-88500000 Lages, SC, Brazil
[3] Univ Fed Ceara, Dept Physiol & Pharmacol, BR-60430270 Fortaleza, Ceara, Brazil
关键词
equisetum arvense; learning; memory; aging; oxidative stress;
D O I
10.1016/j.pbb.2005.04.012
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The aim of this work was to verify if chronic administration of the hydroalcoholic extract of stems from Equisetum arvense (HAE) reverses the cognitive impairment in aged rats, as well as, evaluates it in vitro antioxidant properties. Chronic administration of HAE at dose of 50 mg/kg, i.p., improved both short- and long-term retention of inhibitory avoidance task and ameliorated the cognitive performance in reference and working memory version of the Morris Water Maze. No differences were found between all three groups of young controls, aged controls and EHA-treated animals with regard to the open field and elevated plus maze tests. Indeed, no toxicity manifestations were observed during treatment. In vitro assays revealed that HAE diminished the thiobarbituric acid reactive substances as well as nitrite formation, but did not alter catalase activity. Thus, the cognitive enhancement effects of the HAE may be attributed, at least in part, to it antioxidant action. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:593 / 600
页数:8
相关论文
共 47 条
  • [1] The effect of ethanol on lipid peroxidation and glutathione level in the brain stem of rat
    Agar, E
    Bosnak, M
    Amanvermez, R
    Demír, S
    Ayyildiz, M
    Çelík, C
    [J]. NEUROREPORT, 1999, 10 (08) : 1799 - 1801
  • [2] TESTS FOR EMOTIONALITY IN RATS AND MICE - REVIEW
    ARCHER, J
    [J]. ANIMAL BEHAVIOUR, 1973, 21 (MAY) : 205 - 235
  • [3] Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases
    Auddy, B
    Ferreira, M
    Blasina, F
    Lafon, L
    Arredondo, F
    Dajas, F
    Tripathi, PC
    Seal, T
    Mukherjee, B
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2003, 84 (2-3) : 131 - 138
  • [4] Broudiscou LP, 2000, REPROD NUTR DEV, V40, P431, DOI 10.1051/rnd:2000110
  • [5] OXYGEN-FREE RADICALS IN RAT LIMBIC STRUCTURES AFTER KAINATE-INDUCED SEIZURES
    BRUCE, AJ
    BAUDRY, M
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1995, 18 (06) : 993 - 1002
  • [6] REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE
    CARNEY, JM
    STARKEREED, PE
    OLIVER, CN
    LANDUM, RW
    CHENG, MS
    WU, JF
    FLOYD, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3633 - 3636
  • [7] ASSAY OF CATALASES AND PEROXIDASES
    CHANCE, B
    MAEHLY, AC
    [J]. METHODS IN ENZYMOLOGY, 1955, 2 : 764 - 775
  • [8] Memory enhancing activity of Glycyrrhiza glabra in mice
    Dhingra, D
    Parle, M
    Kulkarni, SK
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2004, 91 (2-3) : 361 - 365
  • [9] Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of stems from Equisetum arvense L. in mice
    Do Monte, FHM
    dos Santos, JG
    Russi, M
    Lanziotti, VMNB
    Leal, LKAM
    Cunha, GMD
    [J]. PHARMACOLOGICAL RESEARCH, 2004, 49 (03) : 239 - 243
  • [10] Effect of the spin-trapping compound n-tert-butyl-alpha-phenylnitrone on protein oxidation and life span
    Dubey, A
    Forster, MJ
    Sohal, RS
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 324 (02) : 249 - 254