How to estimate time of infection with Toxoplasma gondii in pregnant women. Use of specific IgG and IgM kinetics by 7 techniques on 691 sera

被引：13
作者：
Fricker-Hidalgo, Helene [1 ,2 ]
Bailly, Sebastien [3 ,4 ]
Brenier-Pinchart, Marie-Pierre [1 ,2 ]
Dard, Celine [1 ,2 ]
Jean, Dominique [5 ]
Coston, Anne-Laure [6 ]
Garnaud, Cecile [1 ,2 ]
Pelloux, Herve [1 ,2 ]
机构：
[1] Grenoble Alps Univ Hosp, Lab Parasitol & Mycol, CS 10217, F-38043 Grenoble, France
[2] Univ Grenoble Alps, Inst Adv Biosci, INSERM, CNRS,UMR 5309,U1209, Grenoble, France
[3] Univ Grenoble Alps, HP2 Lab, INSERM U1042, Grenoble, France
[4] Grenoble Alps Univ Hosp, Thorax & Vessels Ctr, EFCR Lab, Grenoble, France
[5] Grenoble Alps Univ Hosp, Pluridisciplinary Ctr Prenatal Diag, CS 10217, F-38043 Grenoble, France
[6] Grenoble Alps Univ Hosp, Dept Gynecol & Obstet, CS 10217, F-38043 Grenoble, France
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2020年 / 96卷 / 04期
关键词：
Congenital toxoplasmosis; Date of infection; Pregnant women; NATIONAL REFERENCE CENTER; SEROLOGICAL DIAGNOSIS; TOXO IGG; AVIDITY; ASSAYS;
D O I：
10.1016/j.diagmicrobio.2020.114987
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A difficulty when detecting both anti-Toxoplasma gondii-specific IgG and IgM in pregnant women is estimating the date of infection. The aim of this study was to compare the anti-Toxoplasma-specific immunoglobulin kinetics of 7 serological techniques to date the infection and to draw kinetic curves that are easy to use on a daily basis. IgG and IgM antibodies were measured on 691 sera samples. IgM appeared a few days, less than 1 week, after the beginning of the infection. Then, the levels of IgM reached a peak at approximately 3, 4, and 5 weeks with Toxo-ISAGA (R) IgM, IgM homemade indirect immunofluorescence assays, and Vidas Toxo (R) IgM, respectively. Furthermore, the Architect Toxo (R) IgG titers were higher than those of the Vidas Toxo (R) IgG results in recent infection (less than 6 months). This study provides new average IgM and IgG curves that can help to determine the approximate date of infection. (C) 2020 Elsevier Inc. All rights reserved.
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页数：6
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