L-Proline: Applications of a Versatile Amino Acid in the Areas of Medicinal Chemistry and Organic Synthesis

被引：0
作者：
Rodrigues, Searitha C. [1 ]
Lucio, Kaio R. [1 ]
Martins, Maria Tereza M. [1 ]
Silva, Isabela de O. [1 ]
de Moraes, Raphael Silva M. [1 ]
Dias, Flaviana Rodrigues F. [1 ]
Cunha, Anna C. [1 ]
机构：
[1] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Programa Posgrad Quim, Campus Valonguinho, BR-24020141 Niteroi, RJ, Brazil
来源：
REVISTA VIRTUAL DE QUIMICA | 2022年 / 14卷 / 05期
关键词：
L-proline; bioactive compounds; organocatalyst; ASYMMETRIC ALDOL REACTIONS; DIELS-ALDER REACTION; MICHAEL ADDITION; MANNICH; CAPTOPRIL; PEPTIDES; KETONES; PHARMACEUTICALS; ORGANOCATALYSIS; HYDROXYPROLINE;
D O I：
10.21577/1984-6835.20220015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
L-proline is a natural amino acid, which stands out due to the diversity of its applications in the most varied areas. Chemical structural modifications in proline have led to the formation of compounds with different biological activities such as antihypertensive, antitumor, antiparasitic and antiviral. Some examples of asymmetric reactions mediated by L-Proline include aldolic, Mannich, Michael, Diels-Alder, Morita-Baylis-Hillman and Hajos-Parrish-Eder-Sauer-Wiechert reactions and are also reported in this work.
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收藏
页码：824 / 842
页数：19
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