Evolution of pulmonary function after treatment with goserelin in patients with lymphangioleiomyomatosis

被引：18

作者：

Baldi, Bruno Guedes ^{[1
]}

Medeiros Junior, Pedro ^{[1
]}

Pimenta, Suzana Pinheiro ^{[1
]}

Lopes, Roberto Iglesias ^{[2
]}

Kairalla, Ronaldo Adib ^{[1
]}

Ribeiro Carvalho, Carlos Roberto ^{[1
]}

机构：

[1] Univ Sao Paulo, Div Pneumol, InCor, Hosp Clin,Fac Med, Sao Paulo, Brazil

[2] Univ Sao Paulo, Div Urol, Hosp Clin, Fac Med, Sao Paulo, Brazil

来源：

JORNAL BRASILEIRO DE PNEUMOLOGIA | 2011年 / 37卷 / 03期

关键词：

Lymphangioleiomyomatosis; Spirometry; Goserelin; LUNG-FUNCTION; PROGESTERONE; LYMPHANGIOMYOMATOSIS; EFFICACY; HORMONE; DECLINE; ANALOG;

D O I：

10.1590/S1806-37132011000300015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In the atypical smooth muscle cells that are characteristic of lymphangioleiomyomatosis (LAM), there are estrogen and progesterone receptors. Therefore, anti-hormonal therapy, despite having produced controversial results, can be considered a treatment option. The objective of this retrospective study was to evaluate hormonal and spirometric data for nine women with LAM after one year of treatment with goserelin. The mean increase in FEV(1) and FVC was 80 mL and 130 mL, respectively. There was effective blockage of the hormonal axis. It is still not possible to exclude a potential beneficial effect of the use of gonadotropin-releasing hormone analogues in LAM patients, which underscores the need for randomized trials.

引用

页码：375 / 379

页数：5

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