Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

被引：705

作者：

Hagerman, RJ

Leehey, M

Heinrichs, W

Tassone, F

Wilson, R

Hills, J

Grigsby, J

Gage, B

Hagerman, PJ

机构：

[1] Univ Calif Davis, Med Ctr, MIND Inst, Sacramento, CA 95817 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA

[4] Childrens Hosp, Fragile X Treatment & Res Ctr, Denver, CO 80218 USA

[5] Univ Calif Davis, Sch Med, Dept Biol Chem, Stockton, CA USA

[6] Kaiser Permanente, Stockton, CA USA

来源：

NEUROLOGY | 2001年 / 57卷 / 01期

关键词：

D O I：

10.1212/WNL.57.1.127

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.

引用

页码：127 / 130

页数：4

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