Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example

被引：15
作者：
Li, Xiang-Guo [1 ,2 ,3 ]
Roivainen, Anne [1 ,2 ,4 ]
Bergman, Jorgen [1 ,2 ,3 ]
Heinonen, Arttu [5 ]
Bengel, Frank [6 ]
Thum, Thomas [7 ]
Knuuti, Juhani [1 ,2 ]
机构：
[1] Univ Turku, Turku PET Ctr, FI-20521 Turku, Finland
[2] Turku Univ Hosp, FI-20521 Turku, Finland
[3] Abo Akad Univ, Accelerator Lab, FI-25200 Turku, Finland
[4] Univ Turku, Turku Ctr Dis Modeling, FI-20014 Turku, Finland
[5] Turku Ctr Biotechnol, Prote Facil, FI-20014 Turku, Finland
[6] Hannover Med Sch, Dept Nucl Med, Hannover, Germany
[7] Hannover Med Sch, IMTTS, Hannover, Germany
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 48期
基金：
芬兰科学院;
关键词：
AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; PEPTIDE; PET; BIOCONJUGATION; BICYCLONONYNES; MICRORNA; CELLS;
D O I：
10.1039/c5cc02618k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A bicyclononyne-based prosthetic group has been developed for F-18-labeling of anti-microRNA-21, an oligonucleotide, in a near-stoichiometric manner.
引用
收藏
页码：9821 / 9824
页数：4
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