Salaprinol and ponkoranol with thiosugar sulfonium sulfate structure from Salacia prinoides and α-glucosidase inhibitory activity of ponkoranol and kotalanol desulfate

被引：76

作者：

Yoshikawa, Masayuki ^{[1
]}

Xu, Fengming ^{[1
]}

Nakamura, Seikou ^{[1
]}

Wang, Tao ^{[1
]}

Matsuda, Hisashi ^{[1
]}

Tanabe, Genzoh ^{[2
]}

Muraoka, Osamu ^{[2
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Kinki Univ, Sch Pharm, Osaka 5778502, Japan

来源：

HETEROCYCLES | 2008年 / 75卷 / 06期

关键词：

Salacia prinoides; Indian traditional medicine; inhibitory activity against alpha-glucosidase; thiosugar sulfonium sulfate;

D O I：

10.3987/COM-07-11315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The methanolic extract from the roots and stems of Indian Salacia prinoides and its water-eluted fraction of Diaion HP-20 column were found to exhibit inhibitory activities against cc-glucosidase. From the water-eluted fraction, two new unique constituents with thiosugar sulfonium sulfate, salaprinol (1) and porkoranol (2), were isolated together with 10 known constituents including salacinol and kotalanol. The structures of 1 and 2 were elucidated on the basis of chemical and physicochemical evidence. Furthermore, ponkoranol (2) and kotalanol desulfate (14) were found to show potent inhibitory activities against alpha-glucosidase.

引用

页码：1397 / 1405

页数：9

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