Lipoprotein(a) in Alzheimer, Atherosclerotic, Cerebrovascular, Thrombotic, and Valvular Disease Mendelian Randomization Investigation

被引:67
作者
Larsson, Susanna C. [1 ,3 ]
Gill, Dipender [4 ]
Mason, Amy M. [5 ]
Jiang, Tao [5 ]
Back, Magnus [2 ,6 ]
Butterworth, Adam S. [5 ,7 ,8 ,9 ]
Burgess, Stephen [5 ,10 ]
机构
[1] Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Inst Environm Med, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Med, Ctr Mol Med, Stockholm, Sweden
[3] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
[4] Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, St Marys Hosp, London, England
[5] Univ Cambridge, Cardiovasc Epidemiol Unit, British Heart Fdn, Dept Publ Hlth & Primary Care, Cambridge, England
[6] Karolinska Univ Hosp, Heart & Vasc Theme, Div Valvular & Coronary Dis, Stockholm, Sweden
[7] Univ Cambridge, Natl Inst Hlth Res, Blood & Transplant Unit Donor Hlth & Genom, Cambridge, England
[8] Univ Cambridge, Hlth Data Res UK Cambridge, Wellcome Genome Campus, Cambridge, England
[9] Univ Cambridge, British Heart Fdn, Ctr Res Excellence, Cambridge, England
[10] Univ Cambridge, MRC Biostat Unit, Cambridge, England
基金
英国经济与社会研究理事会; 英国医学研究理事会; 英国惠康基金; 瑞典研究理事会; 英国工程与自然科学研究理事会;
关键词
Alzheimer disease; atherosclerosis; heart valve diseases; lipoprotein(a); Mendelian randomization analysis; stroke;
D O I
10.1161/CIRCULATIONAHA.120.045826
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1826 / 1828
页数:3
相关论文
共 5 条
  • [1] Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies A Mendelian Randomization Analysis
    Burgess, Stephen
    Ference, Brian A.
    Staley, James R.
    Freitag, Daniel F.
    Mason, Amy M.
    Nielsen, Sune F.
    Willeit, Peter
    Young, Robin
    Surendran, Praveen
    Karthikeyan, Savita
    Bolton, Thomas R.
    Peters, James E.
    Kamstrup, Pia R.
    Tybjaerg-Hansen, Anne
    Benn, Marianne
    Langsted, Anne
    Schnohr, Peter
    Vedel-Krogh, Signe
    Kobylecki, Camilla J.
    Ford, Ian
    Packard, Chris
    Trompet, Stella
    Jukema, J. Wouter
    Sattar, Naveed
    Di Angelantonio, Emanuele
    Saleheen, Danish
    Howson, Joanna M. M.
    Nordestgaard, Borge G.
    Butterworth, Adam S.
    Danesh, John
    [J]. JAMA CARDIOLOGY, 2018, 3 (07) : 619 - 627
  • [2] Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels
    Emdin, Connor A.
    Khera, Amit V.
    Natarajan, Pradeep
    Klarin, Derek
    Won, Hong-Hee
    Peloso, Gina M.
    Stitziel, Nathan O.
    Nomura, Akihiro
    Zekavat, Seyedeh M.
    Bick, Alexander G.
    Gupta, Namrata
    Asselta, Rosanna
    Duga, Stefano
    Merlini, Piera Angelica
    Correa, Adolfo
    Kessler, Thorsten
    Wilson, James G.
    Bown, Matthew J.
    Hall, Alistair S.
    Braund, Peter S.
    Samani, Nilesh J.
    Schunkert, Heribert
    Marrugat, Jaume
    Elosua, Roberto
    McPherson, Ruth
    Farrall, Martin
    Watkins, Hugh
    Willer, Cristen
    Abecasis, Goncalo R.
    Felix, Janine F.
    Vasan, Ramachandran S.
    Lander, Eric
    Rader, Daniel J.
    Danesh, John
    Ardissino, Diego
    Gabriel, Stacey
    Saleheen, Danish
    Kathiresan, Sekar
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (25) : 2761 - 2772
  • [3] Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes
    Gudbjartsson, Daniel F.
    Thorgeirsson, Gudmundur
    Sulem, Patrick
    Helgadottir, Anna
    Gylfason, Arnaldur
    Saemundsdottir, Jona
    Bjornsson, Eythor
    Norddahl, Gudmundur L.
    Jonasdottir, Aslaug
    Jonasdottir, Adalbjorg
    Eggertsson, Hannes P.
    Gretarsdottir, Solveig
    Thorleifsson, Gudmar
    Indridason, Olafur S.
    Palsson, Runolfur
    Jonasson, Fridbert
    Jonsdottir, Ingileif
    Eyjolfsson, Gudmundur I.
    Sigurdardottir, Olof
    Olafsson, Isleifur
    Danielsen, Ragnar
    Matthiasson, Stefan E.
    Kristmundsdottir, Snaedis
    Halldorsson, Bjarni V.
    Hreidarsson, Astradur B.
    Valdimarsson, Einar M.
    Gudnason, Thorarinn
    Benediktsson, Rafn
    Steinthorsdottir, Valgerdur
    Thorsteinsdottir, Unnur
    Holm, Hilma
    Stefansson, Kari
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (24) : 2982 - 2994
  • [4] Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study
    Pan, Yuesong
    Li, Hao
    Wang, Yilong
    Meng, Xia
    Wang, Yongjun
    [J]. STROKE, 2019, 50 (12) : 3532 - 3539
  • [5] Genetic Associations with Valvular Calcification and Aortic Stenosis
    Thanassoulis, George
    Campbell, Catherine Y.
    Owens, David S.
    Smith, J. Gustav
    Smith, Albert V.
    Peloso, Gina M.
    Kerr, Kathleen F.
    Pechlivanis, Sonali
    Budoff, Matthew J.
    Harris, Tamara B.
    Malhotra, Rajeev
    O'Brien, Kevin D.
    Kamstrup, Pia R.
    Nordestgaard, Borge G.
    Tybjaerg-Hansen, Anne
    Allison, Matthew A.
    Aspelund, Thor
    Criqui, Michael H.
    Heckbert, Susan R.
    Hwang, Shih-Jen
    Liu, Yongmei
    Sjogren, Marketa
    van der Pals, Jesper
    Kaelsch, Hagen
    Muehleisen, Thomas W.
    Noethen, Markus M.
    Cupples, L. Adrienne
    Caslake, Muriel
    Di Angelantonio, Emanuele
    Danesh, John
    Rotter, Jerome I.
    Sigurdsson, Sigurdur
    Wong, Quenna
    Erbel, Raimund
    Kathiresan, Sekar
    Melander, Olle
    Gudnason, Vilmundur
    O'Donnell, Christopher J.
    Post, Wendy S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (06) : 503 - 512