Synapses between NG2 glia and neurons

被引：43
作者：
Sakry, Dominik [1 ]
Karram, Khalad [1 ]
Trotter, Jacqueline [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Dept Biol, D-55128 Mainz, Germany
来源：
JOURNAL OF ANATOMY | 2011年 / 219卷 / 01期
关键词：
myelination; neuron; NG2; oligodendrocyte precursor cells; synapse; OLIGODENDROCYTE PRECURSOR CELLS; CENTRAL-NERVOUS-SYSTEM; WHITE-MATTER; PROGENITOR CELLS; NG2-EXPRESSING CELLS; CHANNEL EXPRESSION; CORPUS-CALLOSUM; AMPA RECEPTORS; GLUTAMATE; ASTROCYTES;
D O I：
10.1111/j.1469-7580.2011.01359.x
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
NG2-expressing glia are precursors to oligodendrocytes and subpopulations of astrocytes. They are unique among glial cells in that they enter into synaptic specialisations with neurons throughout all areas of grey and white matter and at all ages. To date, the NG2 cells appear to represent a postsynaptic compartment, and synapses are formed with axons. With differentiation to oligodendrocytes, NG2 is downregulated and myelin antigens upregulated: this coincides with a loss of the synaptic contacts between neurons and NG2 glial cells. The functional roles of this glial-neuron synapse in regulation of differentiation into myelinating oligodendrocytes or additionally responding to and modulating neuronal network activity remain to be elucidated.
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页码：2 / 7
页数：6
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