Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats

被引：45
作者：
Akcan, Alper [1 ]
Kucuk, Can [1 ]
Sozuer, Erdogan [1 ]
Esel, Duygu [2 ]
Akyildiz, Hizir [1 ]
Akgun, Hulya [3 ]
Muhtaroglu, Sabahattin [4 ]
Aritas, Yucel [1 ]
机构：
[1] Erciyes Univ, Sch Med, Dept Gen Surg, TR-38039 Kayseri, Turkey
[2] Erciyes Univ, Sch Med, Dept Microbiol, TR-38039 Kayseri, Turkey
[3] Erciyes Univ, Sch Med, Dept Pathol, TR-38039 Kayseri, Turkey
[4] Erciyes Univ, Sch Med, Dept Biochem, TR-38039 Kayseri, Turkey
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 06期
关键词：
melatonin; colitis; bacterial translocation; apoptosis; INFLAMMATORY-BOWEL-DISEASE; MESENTERIC LYMPH-NODES; TNBS-INDUCED COLITIS; ULCERATIVE-COLITIS; EPITHELIAL-CELLS; CROHNS-DISEASE; IMMUNE-SYSTEM; MODEL; COLON; EXPRESSION;
D O I：
10.3748/wjg.14.918
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the effects of exogenous; melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS: Rats were randomly assigned to three groups: group I : control, group II : experimental colitis, group III : colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-alpha, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced incidence of bacterial translocation to the liver, spleen, mesenteric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin significantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-treated rats (16.11 +/- 2.46 vs 32.97 +/- 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on bacterial translocation and apoptosis. (C) 2008 WJG, All rights reserved.
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收藏
页码：918 / 924
页数：7
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