Towards Artificial Liver Sinusoids by Dielectrophoretic Cell Assembly in Microfluidic System for Use in Substance Screening

被引：0

作者：

Schuette, J. ^{[1
]}

Angres, B. ^{[1
]}

Benz, K. ^{[1
]}

Freudigmann, C. ^{[1
]}

Hagmeyer, B. ^{[1
]}

Holzner, F. ^{[1
]}

Kubon, M. ^{[1
]}

Boettger, J. ^{[2
]}

Gebhardt, R. ^{[2
]}

Becker, H. ^{[3
]}

Stelzle, M. ^{[1
]}

机构：

[1] NMI Nat Wissensch & Med Inst, Reutlingen, Germany

[2] Univ Leipzig, Inst Biochem, Fak Med, Leipzig, Germany

[3] Microfluid ChipShop GmbH, Jena, Germany

来源：

MICRO-AND NANOSYSTEMS IN MEDICINE, ACTIVE IMPLANTS, BIOSENSORS | 2009年 / 25卷 / 08期

关键词：

liver sinusoid; artificial micro organs; dielectrophoresis; microfluidic device; substance screening; IN-VITRO; DRUG-METABOLISM;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We are developing microfluidic systems with 3D-microstructures and integrated electrodes to assemble cells in an organ-like 3D-structure by means of dielectrophoretic and hydrodynamic forces. To further mimic the in vivo situation cells are allowed to adhere on liver specific extra cellular matrix proteins. Results showing co-assembly of liver cells in a sinusoid like structure will be presented.

引用

页码：161 / +

页数：2

共 9 条

[1] New hepatocyte in vitro systems for drug metabolism:: Metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures [J].