Recognizing nucleotides by cross-tunneling currents for DNA sequencing

被引：14

作者：

Bagci, V. M. K. ^{[1
]}

Kaun, Chao-Cheng ^{[1
,2
]}

机构：

[1] Acad Sinica, Res Ctr Appl Sci, Taipei 11529, Taiwan

[2] Natl Tsing Hua Univ, Dept Phys, Hsinchu 30013, Taiwan

来源：

PHYSICAL REVIEW E | 2011年 / 84卷 / 01期

关键词：

MOLECULE;

D O I：

10.1103/PhysRevE.84.011917

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Using first-principles calculations, we study electron transport through nucleotides inside a rectangular nanogap formed by two pairs of gold electrodes which are perpendicular and parallel to the nucleobase plane. We propose that this setup will enhance the nucleotide selectivity of tunneling signals to a great extent. Information from three electrical probing processes offers full nucleotide recognition, which survives the noise from neighboring nucleotides and configuration fluctuations.

引用

页数：4

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