An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

被引：35

作者：

Baumann, Marcus ^{[1
]}

Baxendale, Ian R. ^{[1
]}

Brasholz, Malte ^{[1
]}

Hayward, John J. ^{[1
]}

Ley, Steven V. ^{[1
]}

Nikbin, Nikzad ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

SYNLETT | 2011年 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

oxazoles; Claisen condensation; flow chemistry; microreactors; solid-supported reagents; MULTISTEP SYNTHESIS; BENGAZOLE-A; CHEMISTRY; REACTOR; POTENT; EFFICIENT; REAGENTS; OPTIMIZATION; TECHNOLOGY; CONVERSION;

D O I：

10.1055/s-0030-1260573

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purification afforded the natural product in a total of nine steps.

引用

页码：1375 / 1380

页数：6

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