An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

被引：34
作者：
Baumann, Marcus [1 ]
Baxendale, Ian R. [1 ]
Brasholz, Malte [1 ]
Hayward, John J. [1 ]
Ley, Steven V. [1 ]
Nikbin, Nikzad [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England
来源：
SYNLETT | 2011年 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
oxazoles; Claisen condensation; flow chemistry; microreactors; solid-supported reagents; MULTISTEP SYNTHESIS; BENGAZOLE-A; CHEMISTRY; REACTOR; POTENT; EFFICIENT; REAGENTS; OPTIMIZATION; TECHNOLOGY; CONVERSION;
D O I：
10.1055/s-0030-1260573
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purification afforded the natural product in a total of nine steps.
引用
收藏
页码：1375 / 1380
页数：6
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