CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy

被引：34
作者：
Abdo, W. F. [1 ,2 ]
de Warrenburg, B. P. C. van [1 ,2 ]
Kremer, H. P. H. [1 ]
Bloem, B. R. [1 ,2 ]
Verbeek, M. M. [1 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Nijmegen Med Ctr, Inst Neurol, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Parkinson Ctr Nijmegen, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Nijmegen Med Ctr, Lab Pediat & Neurol, Nijmegen, Netherlands
来源：
PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 08期
关键词：
multiple system atrophy; CSF; biomarkers; neurofilaments; neurotransmitter metabolites;
D O I：
10.1016/j.parkreldis.2007.02.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background. Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile. Methods: We analyzed brain specific proteins and neurotransmitter metabolites in cerebrospinal fluid (CSF) of 26 patients with MSA-C and 19 with MSA-P. Results: No differences were found between MSA-C and MSA-P. Conclusion: Our results suggest that the clinical and in part pathological distinction between the two clinical MSA phenotypes is not reflected by the neurochemical composition of CSF. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：480 / 482
页数：3
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