PhaSepDB: a database of liquid-liquid phase separation related proteins

被引：160

作者：

You, Kaiqiang ^{[1
]}

Huang, Qi ^{[1
]}

Yu, Chunyu ^{[1
]}

Shen, Boyan ^{[1
]}

Sevilla, Cristoffer ^{[2
]}

Shi, Minglei ^{[3
,4
]}

Hermjakob, Henning ^{[2
,5
]}

Chen, Yang ^{[3
,4
]}

Li, Tingting ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China

[2] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[3] Tsinghua Univ, Dept Automat, Bioinformat Div, MOE Key Lab Bioinformat,BNRist, Beijing 100084, Peoples R China

[4] Tsinghua Univ, Dept Automat, Ctr Synthet & Syst Biol, BNRist, Beijing 100084, Peoples R China

[5] Beijing Inst Life Omics, State Key Lab Prote, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, Beijing 102206, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2020年 / 48卷 / D1期

基金：

中国国家自然科学基金;

关键词：

CAJAL BODIES; COMPLEXITY; GRANULES; DIVERSITY; DYNAMICS; DROPLETS; FORM;

D O I：

10.1093/nar/gkz847

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It's widely appreciated that liquid-liquid phase separation (LLPS) underlies the formation of membraneless organelles, which function to concentrate proteins and nucleic acids. In the past few decades, major efforts have been devoted to identify the phase separation associated proteins and elucidate their functions. To better utilize the knowledge dispersed in published literature, we developed PhaSepDB (http://db.phasep.pro/), a manually curated database of phase separation associated proteins. Currently, PhaSepDB includes 2914 non-redundant proteins localized in different organelles curated from published literature and database. PhaSepDB provides protein summary, publication reference and sequence features of phase separation associated proteins. The sequence features which reflect the LLPS behavior are also available for other human protein candidates. The online database provides a convenient interface for the research community to easily browse, search and download phase separation associated proteins. As a centralized resource, we believe PhaSepDB will facilitate the future study of phase separation.

引用

页码：D354 / D359

页数：6

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