Identification of quorum-sensing-regulated genes of Burkholderia cepacia

被引：37
作者：
Aguilar, C [1 ]
Friscina, A [1 ]
Devescovi, G [1 ]
Kojic, M [1 ]
Venturi, V [1 ]
机构：
[1] Int Ctr Genet Engn & Biotechnol, Bacteriol Grp, I-34012 Trieste, Italy
来源：
JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 21期
关键词：
D O I：
10.1128/JB.185.21.6456-6462.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Quorum sensing is a regulatory mechanism (operating in response to cell density) which in gram-negative bacteria usually involves the production of N-acyl homoserine lactones (HSL). Quorum sensing in Burkholderia cepacia has been associated with the regulation of expression of extracellular proteins and siderophores and also with the regulation of swarming and biofilm formation. In the present study, several quorum-sensing-controlled gene promoters of B. cepacia ATCC 25416 were identified and characterized. A total of 28 putative gene promoters show CepR-C-8-HSL-dependent expression, suggesting that quorum sensing in B. cepacia is a global regulatory system.
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页码：6456 / 6462
页数：7
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