Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population

被引：20

作者：

Trout, Andrew T. ^{[1
]}

Chow, Jeanne ^{[4
]}

McNamara, Erin R. ^{[5
]}

Darge, Kassa ^{[6
,7
]}

Grueso, Raul Ramirez ^{[6
]}

Munden, Marthe ^{[8
]}

Rothan, Sarah M. ^{[10
]}

Navarro, Oscar M. ^{[11
,13
]}

Bueno, Marta Tijerin ^{[11
,13
]}

Bove, Kevin E. ^{[2
]}

Chikwava, Kudakwashe R. ^{[14
]}

Heider, Amer ^{[15
]}

Hicks, M. John ^{[9
,16
]}

Somers, Gino R. ^{[12
]}

Zhang, Bin ^{[3
]}

Dillman, Jonathan R. ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Dept Radiol, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Pathol, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[3] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[4] Boston Childrens Hosp, Dept Radiol, Boston, MA USA

[5] Boston Childrens Hosp, Dept Urol, Boston, MA USA

[6] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA

[7] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[8] Texas Childrens Hosp, Dept Radiol, Houston, TX 77030 USA

[9] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA

[10] Univ Texas Hlth Sci Ctr Houston UTHealth, McGovern Med Sch, Houston, TX USA

[11] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON, Canada

[12] Hosp Sick Children, Div Pathol, Toronto, ON, Canada

[13] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[14] Nemours Alfred I DuPont Hosp Children, Dept Pathol, Orlando, FL USA

[15] Univ Michigan Hlth Syst, Dept Pathol, Ann Arbor, MI USA

[16] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

RADIOLOGY | 2017年 / 285卷 / 02期

关键词：

FOLLOW-UP; ASYMPTOMATIC POPULATION; PREVALENCE; CANCER; TUMOR; MEN; CHILDREN; RISK;

D O I：

10.1148/radiol.2017162625

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To retrospectively define the strength of association between testicular microlithiasis and testicular neoplasia in a large geographically diverse pediatric population. Materials and Methods: Retrospective review of scrotal ultrasonographic (US) examination reports and pathology specimens obtained between January 2000 and May 2014 at six academic pediatric hospitals in North America was performed. Reported cases were reviewed to confirm microlithiasis. Radiology and pathology data bases were searched for pathology-proven testicular tumors (benign or malignant germ cell or stromal tumors). Association strength (risk) was expressed in terms of odds ratios (ORs) with and without adjustment for fixed study site effects based on logistic regression. Results: A total of 37 863 individuals underwent scrotal US during the study period. Mean age was 11.1 years +/- 4.7 [standard deviation] in boys with microlithiasis and 9.1 years +/- 5.9 in boys without microlithiasis (P < .001). Microlithiasis was confirmed in 2.90% of patients (1097 of 37 863; range, 1.61%-5.25% across sites). It was unilateral in 21.97% (241 of 1097) of patients and bilateral in 78.0% (856 of 1097). Tumor was identified in 4.64% (51 of 1097) of boys with microlithiasis and 0.33% (122 of 36 766) of boys without (unadjusted OR, 14.65; 95% confidence interval [CI]: 10.29, 20.84; adjusted OR, 14.19). Malignant germ cell tumors were identified in 2.8% (31 of 1097) of boys with microlithiasis and 0.12% (45 of 36 766) of boys without microlithiasis (unadjusted OR, 17.26; 95% CI: 11.8, 25.25; adjusted OR, 22.37). Sex cord-stromal tumors were identified in 0.46% (five of 1097) of boys with microlithiasis and 0.079% (29 of 36 766) of boys without (unadjusted OR, 5.8; 95% CI: 2.1, 16; adjusted OR, 6.39). Conclusion: There is a strong association between testicular microlithiasis and primary testicular neoplasia in this pediatric population. (C) RSNA, 2017

引用

页码：576 / 583

页数：8

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