Abbreviated literature searches were viable alternatives to comprehensive searches: a meta-epidemiological study

被引:47
作者
Nussbaumer-Streit, Barbara [1 ]
Klerings, Irma [1 ]
Wagner, Gernot [1 ]
Heise, Thomas L. [2 ,3 ]
Dobrescu, Andreea I. [4 ]
Armijo-Olivo, Susan [5 ,6 ]
Stratil, Jan M. [7 ]
Persad, Emma [1 ]
Lhachimi, Stefan K. [2 ,3 ]
Van Noord, Megan G. [8 ]
Mitterrnayr, Tarquin [9 ]
Zeeb, Hajo [10 ]
Hemkens, Lars [11 ]
Gartlehner, Gerald [1 ,12 ]
机构
[1] Danube Univ Krems, Cochrane Austria, Dr Karl Dorrek Str 30, A-3500 Krems Ad Donau, Austria
[2] Leibniz Inst Prevent Res & Epidemiol BIPS, Res Grp Evidence Based Publ Hlth, Bremen, Germany
[3] Univ Bremen, Inst Publ Hlth & Nursing Res IPP, Hlth Sci Bremen, Bremen, Germany
[4] Victor Babes Univ Med & Pharm Timisoara, Genet Dept, Timisoara, Romania
[5] Univ Alberta, Fac Rehabil Med, Edmonton, AB, Canada
[6] Inst Hlth Econ, Edmonton, AB, Canada
[7] Ludwig Maximilians Univ Munchen, Pettenkofer Sch Publ Hlth, Inst Med Informat Biometry & Epidemiol, Munich, Germany
[8] Duke Univ, Med Ctr Lib & Arch, Durham, NC USA
[9] Ludwig Boltzmann Inst Hlth Technol Assessment, Vienna, Austria
[10] Leibniz Inst Prevent Res & Epidemiol BIPS, Dept Prevent & Evaluat, Bremen, Germany
[11] Univ Basel, Univ Hosp Basel, Basel Inst Clin Epidemiol & Biostat, Dept Clin Res, Basel, Switzerland
[12] RTI Int, Res Triangle Pk, NC USA
关键词
Literature search; Rapid reviews; Systematic reviews; Abbreviated; Limited; Databases; SYSTEMATIC REVIEWS;
D O I
10.1016/j.jclinepi.2018.05.022
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: To assess the effects of abbreviated literature searches on evidence syntheses conclusions. Study design and setting: We randomly selected 60 Cochrane reviews of clinical interventions and repeated literature searches using 14 abbreviated approaches (combinations of MEDLINE, Embase, CENTRAL with and without searches of reference lists). If abbreviated searches missed included studies, we recalculated meta-analyses. Cochrane authors determined whether the new evidence base would change conclusions. We assessed the noninferiority of abbreviated searches allowing for a maximum of 10% changed conclusions. Results: We conducted 840 abbreviated literature searches. Noninferiority varied based on the definition of "changed conclusion". When the reduction of the certainty of a conclusion was of concern, all abbreviated searches were inferior. Searching Embase only rendered the greatest proportion of changed conclusions (27%, 95% confidence interval [CI]: 16%-40%); combining MEDLINE, Embase, CENTRAL with searches of references lists the lowest (8%, 95% CI 3%-18%). When falsely reaching an opposite conclusion was of concern, combining one database with another or with searches of reference lists was noninferior to comprehensive searches (2%, 95% CI: 0%-9%). Conclusion: If decision-makers are willing to accept less certainty and a small risk for opposite conclusions, some abbreviated searches are viable options for rapid evidence syntheses. Decisions demanding high certainty require comprehensive searches. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:1 / 11
页数:11
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