Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies

被引：77

作者：

Yan, Xuefeng ^{[1
,2
,3
]}

Hu, Hao ^{[2
]}

Lin, Jing ^{[2
]}

Jin, Albert J. ^{[4
]}

Niu, Gang ^{[2
]}

Zhang, Shaoliang ^{[5
]}

Huang, Peng ^{[2
]}

Shen, Baozhong ^{[1
,3
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Harbin Med Univ, Hosp 4, Dept Radiol, Harbin, Heilongjiang, Peoples R China

[2] NIBIB, NIH, Bethesda, MD 20892 USA

[3] Harbin Med Univ, Mol Imaging Ctr, Harbin, Heilongjiang, Peoples R China

[4] NIBIB, Lab Cellular Imaging & Macromol Biophys, NIH, Bethesda, MD 20892 USA

[5] Jiangxi Qinglong Grp Co Ltd, Yichun 336000, Jiangxi, Peoples R China

来源：

NANOSCALE | 2015年 / 7卷 / 06期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

GRAPHENE OXIDE; PHOTODYNAMIC THERAPY; ENHANCED-FLUORESCENCE; NANO-GRAPHENE; GOLD NANORODS; PHOTOSENSITIZER; FUNCTIONALIZATION; NANOPARTICLES; THERANOSTICS;

D O I：

10.1039/c4nr06868h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT), due to their specific spatiotemporal selectivity and minimal invasiveness, have been widely investigated as alternative treatments of malignant diseases. Graphene and its derivatives not only have been used as carriers to deliver photosensitizers for PDT, but also as photothermal conversion agents (PTCAs) for PTT. Herein, we strategically designed and produced a novel photo-theranostic platform based on sinoporphyrin sodium (DVDMS) photosensitizer-loaded PEGylated graphene oxide (GO-PEG-DVDMS) for enhanced fluorescence/photoacoustic (PA) dual-modal imaging and combined PDT and PTT. The GO-PEG carrier drastically improves the fluorescence of loaded DVDMS via intramolecular charge transfer. Concurrently, DVDMS significantly enhances the near-infrared (NIR) absorption of GO for improved PA imaging and PTT. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. This novel theranostics is well suited for fluorescence/PA dual-modal imaging and synergistic PDT/PTT.

引用

页码：2520 / 2526

页数：7

共 36 条

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