Cyclometalated iridium(III) N-heterocyclic carbene complexes as potential mitochondrial anticancer and photodynamic agents

被引：64

作者：

Li, Yi ^{[1
,2
]}

Liu, Bing ^{[1
]}

Lu, Xin-Ran ^{[1
]}

Li, Meng-Feng ^{[2
]}

Ji, Liang-Nian ^{[1
]}

Mao, Zong-Wan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2017年 / 46卷 / 34期

基金：

中国国家自然科学基金;

关键词：

SINGLET OXYGEN SENSITIZERS; ENDOPLASMIC-RETICULUM; CANCER-CELLS; ANTITUMOR METALLODRUGS; TARGETING MITOCHONDRIA; BIOLOGICAL EVALUATION; IR(III) COMPLEXES; METAL-COMPLEXES; CELLULAR UPTAKE; THERAPY;

D O I：

10.1039/c7dt01903c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal N-heterocyclic carbene (NHC) complexes represent a promising class of anticancer therapeutic agents. In this work, four cyclometalated iridium(III) complexes (Ir1-Ir4) containing N-heterocyclic carbene ligands have been explored as mitochondrial anticancer and photodynamic agents. These complexes are more cytotoxic than cisplatin against the cancer cells screened, can quickly penetrate into A549 cells and are mainly localized in the mitochondria. Mechanism studies show that these complexes exert their anticancer efficacy by increasing the intracellular ROS level, reducing the mitochondrial membrane potential (MMP) and inducing apoptosis. Additionally, Ir1-Ir4 exhibited two orders of magnitude higher cytotoxicity upon irradiation at 450 nm LED light. Our work provides a strategy for the design of highly effective anticancer photodynamic therapeutic agent based phosphorescent iridium complexes.

引用

页码：11363 / 11371

页数：9

共 54 条

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