Developmental roles of the glypicans

被引：136

作者：

De Cat, B ^{[1
]}

David, G ^{[1
]}

机构：

[1] Catholic Univ Leuven VIB, Ctr Human Genet, Lab Glycobiol & Dev Genet, B-3000 Louvain, Belgium

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 02期

关键词：

heparan sulfate; lipid rafts; Simpson-Golabi-Behmel syndrome tissue patterning;

D O I：

10.1006/scdb.2000.0240

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glypicans are proteins with very characteristic structures that are substituted with heparan sulfate and that are linked to the cell surface via glycosylphosphatidylinositol. The modular structure of the glypicans has been highly conserved throughout evolution. Six glypicans have been identified so far in vertebrates. Mutations in Drosophila, humans and mice reveal a role for these cell surface molecules in the control of cell growth and differentiation. Their mechanism of action is not yet clear. Most likely, glypicans activate or determine the activity ranges of morphogens and growth factors such as FGFs, BMPs, Wnts, Hhs and IGFs.

引用

页码：117 / 125

页数：9

共 54 条

[1]

Baeg GH, 2001, DEVELOPMENT, V128, P87

[2] Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion [J].

Bellaiche, Y ;

The, I ;

Perrimon, N .

NATURE, 1998, 394 (6688) :85-88

[3]

Brzustowicz LM, 1999, AM J HUM GENET, V65, P1096, DOI 10.1086/302579

[4] Mapping of a new SGBS locus to chromosome Xp22 in a family with a severe form of Simpson-Golabi-Behmel syndrome [J].

Brzustowicz, LM ;

Farrell, S ;

Khan, MB ;

Weksberg, R .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (03) :779-783

[5] Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells [J].

Burke, R ;

Nellen, D ;

Bellotto, M ;

Hafen, E ;

Senti, KA ;

Dickson, BJ ;

Basler, K .

CELL, 1999, 99 (07) :803-815

[6]

Cano-Gauci DF, 1999, J CELL BIOL, V146, P255

[7] Abnormalities of Wnt signalling in schizophrenia - evidence for neurodevelopmental abnormality [J].

Cotter, D ;

Kerwin, R ;

Al-Sarraji, S ;

Brion, JP ;

Chadwich, A ;

Lovestone, S ;

Anderton, B ;

Everall, I .

NEUROREPORT, 1998, 9 (07) :1379-1383

[8] MOLECULAR-CLONING OF A PHOSPHATIDYLINOSITOL-ANCHORED MEMBRANE HEPARAN-SULFATE PROTEOGLYCAN FROM HUMAN LUNG FIBROBLASTS [J].

DAVID, G ;

LORIES, V ;

DECOCK, B ;

MARYNEN, P ;

CASSIMAN, JJ ;

VANDENBERGHE, H .

JOURNAL OF CELL BIOLOGY, 1990, 111 (06) :3165-3176

[9] A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2 [J].

Detera-Wadleigh, SD ;

Badner, JA ;

Berrettini, WH ;

Yoshikawa, T ;

Goldin, LR ;

Turner, G ;

Rollins, DY ;

Moses, T ;

Sanders, AR ;

Karkera, JD ;

Esterling, LE ;

Zeng, J ;

Ferraro, TN ;

Guroff, JJ ;

Kazuba, D ;

Maxwell, ME ;

Nurnberger, JI ;

Gershon, ES .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) :5604-5609

[10] OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth Syndrome, induces apoptosis in a cell line-specific manner [J].

Duenas-Gonzalez, A ;

Kaya, M ;

Shi, W ;

Song, H ;

Testa, JR ;

Penn, LZ ;

Filmus, J .

JOURNAL OF CELL BIOLOGY, 1998, 141 (06) :1407-1414

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