Simplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD?

被引：13

作者：

Oerlemans, Anoek M. ^{[1
,2
]}

Hartman, Catharina A. ^{[3
]}

De Bruijn, Yvette G. E. ^{[1
,2
]}

Van Steijn, Daphne J. ^{[1
]}

Franke, Barbara ^{[4
,5
]}

Buitelaar, Jan K. ^{[1
,2
]}

Rommelse, Nanda N. J. ^{[1
,4
]}

机构：

[1] Univ Ctr Nijmegen, NL-6525 GC Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2015年 / 45卷 / 03期

关键词：

Autism spectrum disorders (ASD); Attention-deficit/hyperactivity disorder (ADHD); Simplex-multiplex stratification; Family; Unaffected relative; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY-DISORDER; AUTISM SPECTRUM DISORDER; QUOTIENT AQ; RELIABILITY; POPULATION; PHENOTYPE; SYMPTOMS; CHILDREN; VALIDITY;

D O I：

10.1007/s10803-014-2220-9

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are highly heterogeneous neuropsychiatric disorders, that frequently co-occur. This study examined whether stratification into single-incidence (SPX) and multi-incidence (MPX) is helpful in (a) parsing heterogeneity and (b) detecting overlapping and unique underpinnings of the disorders. ASD and ADHD traits were measured in 56 ASD/31 ADHD SPX families, 59 ASD/171 ADHD MPX families and 203 control families. In ASD but not ADHD, behavioral traits were less elevated in SPX than MPX unaffected relatives, suggesting that SPX-MPX stratification may thus help parse ASD, but not ADHD heterogeneity. Particularly unaffected relatives from MPX ASD/ADHD families displayed elevated trait levels of both disorders, indicating shared (multifactorial) underpinnings underlying ASD and ADHD in these families. Cross-disorder traits were highest in MPX ASD unaffected siblings.

引用

页码：645 / 657

页数：13

共 53 条

[51] Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis [J].

Williams, Nigel M. ;

Zaharieva, Irina ;

Martin, Andrew ;

Langley, Kate ;

Mantripragada, Kiran ;

Fossdal, Ragnheidur ;

Stefansson, Hreinn ;

Stefansson, Karl ;

Magnusson, Pall ;

Gudmundsson, Olafur O. ;

Gustafsson, Omar ;

Holmans, Peter ;

Owen, Michael J. ;

O'Donovan, Michael ;

Thapar, Anita .

LANCET, 2010, 376 (9750) :1401-1408

[52] Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits [J].

Wong, C. C. Y. ;

Meaburn, E. L. ;

Ronald, A. ;

Price, T. S. ;

Jeffries, A. R. ;

Schalkwyk, L. C. ;

Plomin, R. ;

Mill, J. .

MOLECULAR PSYCHIATRY, 2014, 19 (04) :495-503

[53] Identical But Not the Same: The Value of Discordant Monozygotic Twins in Genetic Research [J].

Zwijnenburg, Petra J. G. ;

Meijers-Heijboer, Hanne ;

Boomsma, Dorret I. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2010, 153B (06) :1134-1149

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