Simplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD?

被引：13

作者：

Oerlemans, Anoek M. ^{[1
,2
]}

Hartman, Catharina A. ^{[3
]}

De Bruijn, Yvette G. E. ^{[1
,2
]}

Van Steijn, Daphne J. ^{[1
]}

Franke, Barbara ^{[4
,5
]}

Buitelaar, Jan K. ^{[1
,2
]}

Rommelse, Nanda N. J. ^{[1
,4
]}

机构：

[1] Univ Ctr Nijmegen, NL-6525 GC Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2015年 / 45卷 / 03期

关键词：

Autism spectrum disorders (ASD); Attention-deficit/hyperactivity disorder (ADHD); Simplex-multiplex stratification; Family; Unaffected relative; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY-DISORDER; AUTISM SPECTRUM DISORDER; QUOTIENT AQ; RELIABILITY; POPULATION; PHENOTYPE; SYMPTOMS; CHILDREN; VALIDITY;

D O I：

10.1007/s10803-014-2220-9

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are highly heterogeneous neuropsychiatric disorders, that frequently co-occur. This study examined whether stratification into single-incidence (SPX) and multi-incidence (MPX) is helpful in (a) parsing heterogeneity and (b) detecting overlapping and unique underpinnings of the disorders. ASD and ADHD traits were measured in 56 ASD/31 ADHD SPX families, 59 ASD/171 ADHD MPX families and 203 control families. In ASD but not ADHD, behavioral traits were less elevated in SPX than MPX unaffected relatives, suggesting that SPX-MPX stratification may thus help parse ASD, but not ADHD heterogeneity. Particularly unaffected relatives from MPX ASD/ADHD families displayed elevated trait levels of both disorders, indicating shared (multifactorial) underpinnings underlying ASD and ADHD in these families. Cross-disorder traits were highest in MPX ASD unaffected siblings.

引用

页码：645 / 657

页数：13

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