3D-Modeling of the Influence of Isomalt, Glucose, and Compaction Pressure on the Quality of Ascorbic-Acid Tablets

The influence of the isomalt mass fraction in a mixture with glucose on the flowability, density, and elastic-plastic properties of the tableting mass and the quality of the obtained 1-g tablets (14 mm diameter) was studied. The flowability of the mixture decreased by 0.6 +/- 0.06 g/c if the isomalt ST-PF content was increased by 10%. The curve for the bulk density had a distinct maximum near an isomalt-glucose ratio of 50:50. The tablet strength increased linearly by 55 +/- 7 and 51 +/- 7 N; the density, by 0.0036 +/- 0.0002 and 0.076 +/- 0.003 g/cm(3); and the disintegration time, by 1.2 +/- 0.2 and 1.7 +/- 02 min if the isomalt ST-PF concentration in the mixture was increased to 35% and the compaction pressure to 350 N/cm(2), respectively.