An insight into aptamer engineered dendrimer for cancer therapy

Aptamers play an important role in biomedical industry due to their great affinity to bind to target site. Due to their targeting potency, an adequate amount of therapeutically active drug could be internalized inside the tumor cells. However, development of functionalized aptamer is hindered due to degradation by endonuclease. A bioconjugation of aptamer based dendrimer delivery could grant a new platform of improved targeted drug delivery system. Dendrimers are synthetic molecule with high ligand binding capability due to presence of enormous functional group on their periphery. Unlike other class of polymer, they serve as a biocompatible and stable vehicle with high drug loading efficiency. In this review, we have discussed about the role of aptamer in pharmaceutical industry along with potential of dendrimer as a novel carrier having high ligand binding capability. The review majorly focused on delivery of anticancer drugs and genetic agents to various neoplastic cells.