Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

被引：30
作者：
Prajumwongs, Piya [1 ]
Weeranantanapan, Oratai [2 ]
Jaroonwitchawan, Thiranut [1 ]
Noisa, Parinya [1 ]
机构：
[1] Suranaree Univ Technol, Inst Agr Technol, Sch Biotechnol, Nakhon Ratchasima 30000, Thailand
[2] Suranaree Univ Technol, Inst Sci, Sch Anat, Nakhon Ratchasima 30000, Thailand
来源：
STEM CELLS INTERNATIONAL | 2016年 / 2016卷
关键词：
FRAGILE-X-SYNDROME; HUMAN ES CELLS; DIRECTED DIFFERENTIATION; IN-VITRO; SELF-RENEWAL; NEURONS; PRECURSORS; PROTEIN; SPECIFICATION; LINES;
D O I：
10.1155/2016/2958210
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation.
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页数：9
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