Multiple sclerosis at menopause: Potential neuroprotective effects of estrogen

被引：31

作者：

Christianson, Mindy S. ^{[1
]}

Mensah, Virginia A. ^{[2
]}

Shen, Wen ^{[3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Lutherville Timonium, MD 21093 USA

[2] Brown Univ, Women & Infants Hosp, Brown Alpert Med Sch, Providence, RI USA

[3] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD 21205 USA

来源：

MATURITAS | 2015年 / 80卷 / 02期

关键词：

Menopause; Multiple sclerosis; Estrogen; Estradiol; Neuroprotection; Hormone therapy; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CRITICAL PERIOD HYPOTHESIS; PREGNANCY HORMONE ESTRIOL; CENTRAL-NERVOUS-SYSTEM; RECEPTOR-ALPHA; DEMYELINATING DISEASE; SEX-DIFFERENCES; MEDIATED NEUROPROTECTION; INDUCED APOPTOSIS;

D O I：

10.1016/j.maturitas.2014.11.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative condition of the central nervous system that preferentially afflicts women more than men. Low estrogen states such as menopause and the postpartum period favor exacerbations of multiple sclerosis in women with the disease. Existing and emerging evidence suggests a role for estrogen in the alleviation of symptoms and reversal of pathology associated with MS. While clinical evidence is sparse regarding the benefit of estrogen therapy for women at risk for MS exacerbations, scientific data demonstrates that estrogen potentiates numerous neuroprotective effects on the central nervous system (CNS). Estrogens play a wide range of roles involved in MS disease pathophysiology, including increasing antiinflammatory cytokines, decreasing demyelination, and enhancing oxidative and energy producing processes in CNS cells. (C) 2014 Published by Elsevier Ireland Ltd.

引用

页码：133 / 139

页数：7

共 96 条

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