MiRNAs and LncRNAs: Dual Roles in TGF-β Signaling-Regulated Metastasis in Lung Cancer

被引：66
|
作者：
Lai, Xing-Ning [1 ]
Li, Jun [1 ]
Tang, Li-Bo [1 ]
Chen, Wen-Tong [1 ]
Zhang, Lei [1 ]
Xiong, Li-Xia [1 ]
机构：
[1] Nanchang Univ, Jiangxi Prov Key Lab Tumor Pathogenesis & Mol Pat, Dept Pathophysiol, Med Coll, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
miRNAs; lncRNAs; TGF-beta signaling; miRNA sponges; lung cancer; metastasis; EPITHELIAL-MESENCHYMAL-TRANSITION; LONG NONCODING RNA; CELL-PROLIFERATION; CIRCULAR RNAS; INHIBITS MIGRATION; DOWN-REGULATION; POOR-PROGNOSIS; IN-VITRO; INVASION; PROMOTES;
D O I：
10.3390/ijms21041193
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lung cancer is one of the most malignant cancers around the world, with high morbidity and mortality. Metastasis is the leading cause of lung cancer deaths and treatment failure. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs), two groups of small non-coding RNAs (nc-RNAs), are confirmed to be lung cancer oncogenes or suppressors. Transforming growth factor-beta (TGF-beta) critically regulates lung cancer metastasis. In this review, we summarize the dual roles of miRNAs and lncRNAs in TGF-beta signaling-regulated lung cancer epithelial-mesenchymal transition (EMT), invasion, migration, stemness, and metastasis. In addition, lncRNAs, competing endogenous RNAs (ceRNAs), and circular RNAs (circRNAs) can act as miRNA sponges to suppress miRNAs, thereby mediating TGF-beta signaling-regulated lung cancer invasion, migration, and metastasis. Through this review, we hope to cast light on the regulatory mechanisms of miRNAs and lncRNAs in TGF-beta signaling-regulated lung cancer metastasis and provide new insights for lung cancer treatment.
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页数：28
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