The analysis of the interaction between the liquid cargo and the tank-semi-trailer shell structure (liquid loading - Fluid Structure Interaction) was performed in the work, evaluating the analysis of situations related to changes in the tanker movement mode, various road macro profiles, dynamic load slopes and turns. Simulations of fluid sloshing in the tank with acceleration were done in different tank constructions. Dynamic analysis was performed using lg negative acceleration, meanwhile in real life conditions tanker truck braking acceleration, using ABS (anti-lock braking system), can reach up to 0.6 g. For static and quasi-static loading cases, the analysis of a fully loaded tank truck - a semi-trailer standing on a horizontal road was performed, as well as the dynamics coefficient was estimated. It was suggested that tanker construction is strong enough but optimization further investigation is necessary. (C) 2020 Vaidas LukoSevie'ius, Zilvinas Bazaras, Vaidas Liesionis, Vytautas Navickas.