Impact of the home indoor environment on adult asthma and rhinitis

Objective: We sought to study the combined effects of multiple home indoor environmental exposures in adult asthma and rhinitis. Methods: We studied 226 adults with asthma and rhinitis by structured interviews and home assessments. Environmental factors included dust allergen, endotoxin and glucan concentrations, and indoor air quality (IAQ) variables. Outcomes included forced expiratory volume in I second (FEV1) percent predicted, Severity of Asthma Score (SAS), Short-Form (SF)-12 Physical Component Scale (PCS), and asthma Quality of Life (QOL) score. Results: House dust-associated exposures together with limited IAQ variables were related to FEV1 % predicted (R-2 = 0.24; P = 0.0001) and SAS (R-2 = 0.18; P = 0.007). IAQ and limited dust variables were associated with SF-12 PCS (R-2 = 0.15; P = 0.02), but not QOL (R-2 = 0.13; P = 0.16). Conclusions: The home environment is strongly linked to lung function, health status, and disease severity, in adult asthma and rhinitis.