Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

被引：39

作者：

Buys, Emmanuel S. ^{[1
]}

Potter, Lincoln R. ^{[2
]}

Pasquale, Louis R. ^{[3
,4
]}

Ksander, Bruce R. ^{[5
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Anesthesia Ctr Crit Care Res,Dept Anesthesia Crit, Boston, MA 02114 USA

[2] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Glaucoma Serv Mass Eye & Ear Infirmary,Dept Ophth, Boston, MA 02114 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02114 USA

[5] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Schepens Eye Res Inst,Dept Ophthalmol, Boston, MA USA

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2014年 / 7卷

关键词：

guanylate cyclase; nitric oxide; natriuretic peptides; glaucoma; open-angle; intraocular pressure; OPEN-ANGLE GLAUCOMA; NITRIC-OXIDE SYNTHASE; NORMAL-TENSION GLAUCOMA; AQUEOUS-HUMOR OUTFLOW; OCULAR PERFUSION-PRESSURE; GENOME-WIDE ASSOCIATION; RETINAL GANGLION-CELLS; OPTIC-NERVE HEAD; NATRIURETIC-PEPTIDE RECEPTORS; VISUAL-FIELD CHARACTERISTICS;

D O I：

10.3389/fnmol.2014.00038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006). By the year 2020, an estimated 80 million people will have glaucoma, 11 million of which will be bilaterally blind. Primary open-angle glaucoma (POAG) is the most common type of glaucoma. Elevated intraocular pressure (IOP) is currently the only risk factor amenable to treatment. How IOP is regulated and can be modulated remains a topic of active investigation. Available therapies, mostly geared toward lowering IOP, offer incomplete protection, and POAG often goes undetected until irreparable damage has been done, highlighting the need for novel therapeutic approaches, drug targets, and biomarkers (Heijl et al., 2002; Quigley, 2011). In this review, the role of soluble (nitric oxide (NO)-activated) and membrane-bound, natriuretic peptide (NP)-activated guanylate cyclases that generate the secondary signaling molecule cyclic guanosine monophosphate (cGMP) in the regulation of IOP and in the pathophysiology of POAG will be discussed.

引用

页数：15

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