Susceptibility of Multiple Primary Cancers in Patients With Head and Neck Cancer: Nature or Nurture?

被引：13

作者：

Zhang, Wei-long ^{[1
]}

Zhuo-li Zhu ^{[1
]}

Huang, Mei-chang ^{[1
]}

Tang, Ya-Jie ^{[2
]}

Tang, Ya-ling ^{[1
]}

Liang, Xin-hua ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[2] Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

基金：

中国国家自然科学基金;

关键词：

head and neck cancer; multiple primary cancer; field cancerization; cancer-associated fibroblasts; genetic factor; biomarker; SQUAMOUS-CELL CARCINOMA; 2ND PRIMARY MALIGNANCY; CODON; 72; POLYMORPHISM; UPPER AERODIGESTIVE TRACT; EARLY-STAGE HEAD; PRIMARY TUMORS; HUMAN-PAPILLOMAVIRUS; FIELD CANCERIZATION; MICROSATELLITE INSTABILITY; GENETIC-VARIANTS;

D O I：

10.3389/fonc.2019.01275

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple primary cancers (MPCs) are major obstacles to long-term survival in head and neck cancer (HNSCC), however, the molecular mechanism underlying multiple carcinogenesis remains unclear. "Field cancerization" is a classical theory to elaborate the malignant progression of MPCs. Apart from environmental and immune factors, genetic factors may have great potential as molecular markers for MPCs risk prediction. This review focuses on inherited and acquired gene mutations in MPCs, including germ-line mutation, single-nucleotide polymorphism, chromosomal instability, microsatellite instability and DNA methylation. And definition and prognosis of MPCs have also been discussed. These may pave the way for the early detection, prevention and effective treatment of MPCs in HNSCC.

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页数：10

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[21] Second primary tumors and their risk factors in patients with primary head and neck tumors [J].

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