Circular RNAs in cardiovascular diseases

被引：36

作者：

Mei, Xiaohan ^{[1
]}

Chen, Shi-You ^{[1
,2
]}

机构：

[1] Univ Missouri, Dept Surg, Sch Med, 1 Hosp Dr, Columbia, MO 65212 USA

[2] Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, Columbia, MO 65212 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2022年 / 232卷

基金：

美国国家卫生研究院;

关键词：

Circular RNAs (circRNAs); Cardiovascular diseases; LONG NONCODING RNAS; MUSCLE-CELL DIFFERENTIATION; MESSENGER-RNA; MYOCARDIAL-INFARCTION; MIRNA; CIRCRNA; PROTEIN; BIOGENESIS; EXPRESSION; DATABASE;

D O I：

10.1016/j.pharmthera.2021.107991

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In eukaryotes, precursor mRNAs (pre-mRNAs) produce a unique class of biologically active molecules namely circular RNAs (circRNAs) with a covalently closed-loop structure via back-splicing. Because of this unconventional circular form, circRNAs exhibit much higher stability than linear RNAs due to the resistance to exonuclease degradation and thereby play exclusive cellular regulatory roles. Recent studies have shown that circRNAs are widely expressed in eukaryotes and display tissue-and disease-specific expression patterns, including in the cardiovascular system. Although numerous circRNAs are discovered by in silico methods, a limited number of circRNAs have been studied. This review intends to summarize the current understanding of the characteristics, biogenesis, and functions of circRNAs and delineate the practical approaches for circRNAs investigation. Moreover, we discuss the emerging roles of circRNAs in cardiovascular diseases. (C) 2021 Elsevier Inc. All rights reserved.

引用

页数：19

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