Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53?

被引：7

作者：

Roemer, Klaus ^{[1
]}

机构：

[1] Univ Saarland, Jose Carreras Res Ctr, Sch Med, D-6650 Homburg, Saar, Germany

来源：

CELL CYCLE | 2010年 / 9卷 / 17期

关键词：

fertility; life expectancy; intelligence; polymorphism; tumor suppression; TUMOR-SUPPRESSOR P53; LIFE-SPAN; ARG72PRO POLYMORPHISM; CANCER; RISK; MORTALITY; NEURONS; REPRODUCTION; METABOLISM; SENESCENCE;

D O I：

10.4161/cc.9.17.13001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent discoveries indicate that the answers to the questions whether we will have children, and if so, how many; for how long we can expect to live; and how fast we are at solving complex intellectual problems, may not be independent of one another but correlated. Although the influence of the environment on fecundity, longevity and cognitive function is, for most of their parts, well documented, it is undisputed that genetic factors impact these issues as well. In the following I have tried to compile some evidence in support of the suggestion that the transcriptional regulator p53 could be one of the molecular underpinnings of the chain of causation that must underlie these correlations.

引用

页码：3438 / 3441

页数：4

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