Application of Flow Cytometry in the Evaluation of Primary Immunodeficiencies

被引：19

作者：

Fleisher, Thomas A. ^{[1
]}

Madkaikar, Manisha ^{[2
]}

Rosenzweig, Sergio D. ^{[1
]}

机构：

[1] NIH, Dept Lab Med, Ctr Clin, Bldg 10,Room 2C306,10 Ctr Dr,MSC1508, Bethesda, MD USA

[2] Natl Inst Immunohaematol ICMR, Dept Pediat Immunol & Leukocyte Biol, KEM Campus, Mumbai, Maharashtra, India

来源：

INDIAN JOURNAL OF PEDIATRICS | 2016年 / 83卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Primary immunodeficiency; Flow cytometry; Diagnosis; DIAGNOSTIC-CRITERIA; DISEASE; TRANSPLANTATION; MUTATIONS;

D O I：

10.1007/s12098-015-2011-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Primary immunodeficiency disorders (PIDDs) are a heterogeneous group of inherited disorders of the immune system. Currently more than 250 different PIDDs with a known genetic defect have been recognized. The diagnosis of many of these disorders is supported strongly by a wide variety of flow cytometry applications. Flow cytometry offers a rapid and sensitive tool for diagnosis and classification of PIDDs. It is applicable in the initial workup and subsequent management of several primary immunodeficiency diseases. As our understanding of the pathogenesis and management of these diseases increases, the majority of these tests can be easily established in the diagnostic laboratory. Thus, the focus of this article is on the application of flow cytometry in the diagnosis and/or evaluation of PIDDs.

引用

页码：444 / 449

页数：6

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