Exploring a benzyloxyaniline linker utilizing ceric ammonium nitrate (CAN) as a cleavage reagent:: Solid-phase synthesis of N-unsubstituted β-lactams and secondary amides

被引：42

作者：

Gordon, KH ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 01期

关键词：

D O I：

10.1021/ol006766l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel benzyloxyaniline linker that uses eerie ammonium nitrate (CAN) as a cleavage reagent is described. Its application in the solid-phase synthesis of N-unsubstituted beta -lactams and secondary amides furnishes compounds in moderate to excellent yield (45-91%) and high purity (93-99%).

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页码：53 / 56

页数：4

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