Mililatensols A-C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis

被引：13

作者：

Bu, Qing ^{[1
]}

Yang, Min ^{[2
]}

Yan, Xian-Yun ^{[1
]}

Li, Song-Wei ^{[2
]}

Ge, Zeng-Yue ^{[1
]}

Zhang, Ling ^{[1
]}

Yao, Li-Gong ^{[2
]}

Guo, Yue-Wei ^{[2
,3
,4
,5
,6
]}

Liang, Lin-Fu ^{[1
]}

机构：

[1] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China

[3] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China

[4] Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China

[5] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China

[6] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 09期

基金：

中国国家自然科学基金;

关键词：

soft coral; Sarcophyton mililatensis; sarsolenane; capnosane; stereochemistry; anti-inflammatory activity; TROCHELIOPHORUM; CEMBRANOIDS;

D O I：

10.3390/md20090566

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three unusual diterpenes with rare sarsolenane and capnosane skeletons, namely mililatensols A-C (1-3), were isolated from the South China Sea soft coral Sarcophyton mililatensis, leading to the first record of sarsolenane and capnosane diterpenes from the title animal. The structures of compounds 1-3 were established by extensive spectroscopic analysis and comparison with the literature data. Moreover, the absolute configuration of 2 was determined by TDDFT ECD calculations. In an in vitro bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-alpha release in RAW264.7 macrophages. In the preliminary virtual screening of inhibitory potential against SARS-CoV-2 by molecular docking, the results showed these three diterpenes were potential SARS-CoV-2 M-pro inhibitors.

引用

页数：10

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