Distinct and overlapping mechanisms of resistance to azacytidine and guadecitabine in acute myeloid leukemia

被引:22
|
作者
Gruber, Emily [1 ,2 ]
Franich, Rheana L. [1 ]
Shortt, Jake [1 ,3 ,4 ]
Johnstone, Ricky W. [1 ,2 ]
Kats, Lev M. [1 ,2 ]
机构
[1] Peter MacCallum Canc Ctr, Melbourne, Vic 3000, Australia
[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia
[3] Monash Hlth, Monash Haematol, Clayton, Vic 3168, Australia
[4] Monash Univ, Monash Hlth, Sch Clin Sci, Clayton, Vic 3168, Australia
基金
英国医学研究理事会;
关键词
MYELODYSPLASTIC SYNDROMES; AZACITIDINE; CANCER; THERAPY;
D O I
10.1038/s41375-020-0973-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:3388 / 3392
页数:5
相关论文
共 50 条
  • [1] Mechanisms of Resistance to Small Molecules in Acute Myeloid Leukemia
    Lang, Tonio Johannes Lukas
    Damm, Frederik
    Bullinger, Lars
    Frick, Mareike
    CANCERS, 2023, 15 (18)
  • [2] Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
    Cremer, Anjali
    Ellegast, Jana M.
    Alexe, Gabriela
    Frank, Elizabeth S.
    Ross, Linda
    Chu, Haihua
    Pikman, Yana
    Robichaud, Amanda
    Goodale, Amy
    Hauepl, Bjorn
    Mohr, Sebastian
    Rao, Arati V.
    Walker, Alison R.
    Blachly, James S.
    Piccioni, Federica
    Armstrong, Scott A.
    Byrd, John C.
    Oellerich, Thomas
    Stegmaier, Kimberly
    CANCER DISCOVERY, 2020, 10 (02) : 214 - 231
  • [3] Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study
    Fenaux, Pierre
    Gobbi, Marco
    Kropf, Patricia L.
    Issa, Jean-Pierre J.
    Roboz, Gail J.
    Mayer, Jiri
    Krauter, Juergen
    Robak, Tadeusz
    Kantarjian, Hagop
    Novak, Jan
    Jedrzejczak, Wieslaw. W.
    Thomas, Xavier
    Ojeda-Uribe, Mario
    Miyazaki, Yasushi
    Min, Yoo Hong
    Yeh, Su-Peng
    Brandwein, Joseph
    Gercheva-Kyuchukova, Liana
    Demeter, Judit
    Griffiths, Elizabeth
    Yee, Karen
    Doehner, Konstanze
    Hao, Yong
    Keer, Harold
    Azab, Mohammad
    Doehner, Hartmut
    BLOOD ADVANCES, 2023, 7 (17) : 5027 - 5037
  • [4] Dose, Schedule, Safety, and Efficacy of Guadecitabine in Relapsed or Refractory Acute Myeloid Leukemia
    Roboz, Gail J.
    Kantarjian, Hagop M.
    Yee, Karen W. L.
    Kropf, Patricia L.
    O'Connell, Casey L.
    Griffiths, Elizabeth A.
    Stock, Wendy
    Daver, Naval G.
    Jabbour, Elias
    Ritchie, Ellen K.
    Walsh, Katherine J.
    Rizzieri, David
    Lunin, Scott D.
    Curio, Tania
    Chung, Woonbok
    Hao, Yong
    Lowder, James N.
    Azab, Mohammad
    Issa, Jean-Pierre J.
    CANCER, 2018, 124 (02) : 325 - 334
  • [5] Transfusion independence and survival in patients with acute myeloid leukemia treated with 5-azacytidine
    Gavillet, Mathilde
    Noetzli, Jasmine
    Blum, Sabine
    Duchosal, Michel A.
    Spertini, Olivier
    Lambert, Jean-Francois
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (12): : 1929 - 1931
  • [6] Azacytidine and erlotinib exert synergistic effects against acute myeloid leukemia
    Lainey, E.
    Wolfromm, A.
    Marie, N.
    Enot, D.
    Scoazec, M.
    Bouteloup, C.
    Leroy, C.
    Micol, J-B
    De Botton, S.
    Galluzzi, L.
    Fenaux, P.
    Kroemer, G.
    ONCOGENE, 2013, 32 (37) : 4331 - 4342
  • [7] Pathogenic Mechanisms in Acute Myeloid Leukemia
    Chakraborty, Sohini
    Park, Christopher Y.
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2022, 23 (11) : 1522 - 1534
  • [8] 5-azacytidine enhances the anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia
    Sutherland, May Kung
    Yu, Changpu
    Anderson, Martha
    Zeng, Weiping
    van Rooijen, Nico
    Sievers, Eric L.
    Grewal, Iqbal S.
    Law, Che-Leung
    MABS, 2010, 2 (04) : 440 - 448
  • [9] Deciphering the Therapeutic Resistance in Acute Myeloid Leukemia
    Gurnari, Carmelo
    Pagliuca, Simona
    Visconte, Valeria
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (22) : 1 - 16
  • [10] 5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia
    Ebelt, Nancy D.
    Manuel, Edwin R.
    CANCERS, 2023, 15 (01)